Phellinus linteus suppresses growth, angiogenesis and invasive behaviour of breast cancer cells through the inhibition of AKT signalling

摘要: The antitumour activity of a medicinal mushroom Phellinus linteus (PL), through the stimulation immune system or induction apoptosis, has been recently described. However, molecular mechanisms responsible for inhibition invasive behaviour cancer cells remain to be addressed. In present study, we demonstrate that PL inhibits proliferation (anchorage-dependent growth) as well colony formation (anchorage-independent highly human breast cells. growth MDA-MB-231 is mediated by cell cycle arrest at S phase upregulation p27Kip1 expression. also suppressed adhesion, migration and invasion suppression secretion urokinase-plasminogen activator from addition, markedly inhibited early event in angiogenesis, capillary morphogenesis aortic endothelial cells, downregulation vascular factor These effects are serine-threonine kinase AKT signalling, because phosphorylation Thr308 Ser473 Taken together, our study suggests potential therapeutic effect against cancer.