Comparative Transcriptome Profiling Reveals Coding and Noncoding RNA Differences in NSCLC from African Americans and European Americans.

摘要: Purpose: To determine whether racial differences in gene and miRNA expression translates to lung tumor biology with clinical relevance African Americans (AAs) European (EAs).Experimental Design: The NCI-Maryland Case Control Study includes seven Baltimore City hospitals is overrepresented AA patients (∼40%). Patients that underwent curative NSCLC surgery between 1998 2014 were enrolled. Comparative molecular profiling used mRNA (n = 22 AAs 19 EAs) 42 55 arrays track paired fresh frozen normal tissues specimens from EAs. Pathway enrichment, predicted drug response, microenvironment infiltration, cancer immunotherapy antigen profiling, target enrichment assessed.Results: AA-enriched differential was characterized by stem cell invasion pathways. Differential tumors EAs primarily proliferation Population-specific partly driven population-specific profiles. Drug susceptibility predictions revealed a strong inverse correlation resistance EA sensitivity the same panel of drugs. Statistically significant M1 M2 macrophage infiltration observed (P < 0.05); however, PD-L1, PD-L2 similar both.Conclusions: transcriptomic clear Increased participation trials are needed integrate, leverage, other information maximize therapeutic benefit both Clin Cancer Res; 23(23); 7412-25. ©2017 AACR.