A Double-Blind Randomized Crossover Study of Oral Thalidomide Versus Placebo for Androgen Dependent Prostate Cancer Treated With Intermittent Androgen Ablation

作者: William D. Figg , Maha H. Hussain , James L. Gulley , Philip M. Arlen , Jeanny B. Aragon-Ching

DOI: 10.1016/J.JURO.2008.11.026

关键词:

摘要: Purpose: We determined whether thalidomide can prolong progression-free survival in men with biochemically recurrent prostate cancer treated limited androgen deprivation therapy.Materials and Methods: A total of 159 patients were enrolled a double-blind randomized trial to determine if improve the efficacy gonadotropin-releasing hormone agonist responsive an increasing specific antigen after primary definitive therapy for cancer. Patients 6 months followed by 200 mg per day oral or placebo (oral phase A). At time progression was restarted additional months. then crossed over opposite drug until B). Testosterone dihydroxytestosterone likewise monitored throughout study.Results: During ora...

参考文章(22)
P R Carroll, N Weidner, J Flax, W Blumenfeld, J Folkman, Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma. American Journal of Pathology. ,vol. 143, pp. 401- 409 ,(1993)
G D Chisholm, R F Deane, G B McKelvie, C D Rennie, E L Gilliland, C P Chilton, M G Royle, N H Townell, J Breakey, S M Cresswell, J Glaholm, G M Sole, J J Bolger, M J Stower, M H Ashken, D A Tolley, F J Bramble, P A Jones, R A Styles, Moffat Lef., R W Glashan, Rhind, A Radley, G J Fellows, J Crowther, B Hafner, S Knight, E Thompson, J Smith, J Burrett, P B Clark, J Boreham, R Peto, L N Jurczyk, B A DeSousa, S Parish, Logie Jrc., Ross Rta., Cox, K Perry, T P Stephenson, K K Sethia, Turner Dtl., M Davies, Harrison Gsm., G F Carswell, Rogers Acn., M Lucas, M R Heal, V Boag, J Hetherington, D Kirk, Charlton Cac., Shepheard Bgf., N A Green, M F Smith, T B Hargreave, Moore Kth., R J Morgan, K N Bullock, Bevis Cra., J B Anderson, A L Stewart, Newling Dwk., B Richards, Grayson Cea., Gaches Cgc., P T Doyle, Robinson Mrg., S Sagar, R J Shearer, C M Evans, R A Jones, Wightman Jak., E R Coulton, J C Smith, M E French, C S Powell, Fernie Cgm., Orr Pgg., M Claridge, Gallegos Crr., G H Urwin, G M Watson, C Roberts, S Griffin, M B Rose, M Fordham, G S Watson, W T Lawrence, R Pollard, P H Smith, M J James, Grant Jbp., J P Ward, R R Hall, M Hehir, J L Williams, R W Thomson, L L Beynon, R J Luck, R Rampling, R S Adib, P English, A McGregor, C D Baumber, J W Blaxland, M H Devereux, R Clack, Immediate versus deferred treatment for advanced prostatic cancer: Initial results of the Medical Research Council trial BJUI. ,vol. 79, pp. 235- 246 ,(1997)
JAMES L. GULLEY, WILLIAM D. FIGG, SETH M. STEINBERG, JANE CARTER, MAHA H. HUSSAIN, WILLIAM L. DAHUT, A PROSPECTIVE ANALYSIS OF THE TIME TO NORMALIZATION OF SERUM ANDROGENS FOLLOWING 6 MONTHS OF ANDROGEN DEPRIVATION THERAPY IN PATIENTS ON A RANDOMIZED PHASE III CLINICAL TRIAL USING LIMITED HORMONAL THERAPY The Journal of Urology. ,vol. 173, pp. 1567- 1571 ,(2005) , 10.1097/01.JU.0000154780.72631.85
Misop Han, Alan W. Partin, Charles R. Pound, Jonathan I. Epstein, Patrick C. Walsh, Long-term biochemical disease-free and cancer-specific survival following anatomic radical retropubic prostatectomy. The 15-year Johns Hopkins experience. Urologic Clinics of North America. ,vol. 28, pp. 555- 565 ,(2001) , 10.1016/S0094-0143(05)70163-4
Shin Wakui, Masakuni Furusato, Takaaki Itoh, Hiroshi Sasaki, Akihito Akiyama, Ikuhiro Kinoshita, Koji Asano, Takaaki Tokuda, Shigeo Aizawa, Shinichiro Ushigome, Tumour angiogenesis in prostatic carcinoma with and without bone marrow metastasis: a morphometric study. The Journal of Pathology. ,vol. 168, pp. 257- 262 ,(1992) , 10.1002/PATH.1711680303
James L. Gulley, Jeanny B. Aragon-Ching, Seth M. Steinberg, Maha H. Hussain, Oliver Sartor, Celestia S. Higano, Daniel P. Petrylak, Gurkamal S. Chatta, Philip M. Arlen, William D. Figg, William L. Dahut, Kinetics of Serum Androgen Normalization and Factors Associated With Testosterone Reserve After Limited Androgen Deprivation Therapy for Nonmetastatic Prostate Cancer Journal of Urology. ,vol. 180, pp. 1432- 1437 ,(2008) , 10.1016/J.JURO.2008.06.017
William D. Figg, Sangeeta Raje, Kenneth S. Bauer, Anne Tompkins, David Venzon, Raymond Bergan, Alice Chen, Michael Hamilton, James Pluda, Eddie Reed, Pharmacokinetics of thalidomide in an elderly prostate cancer population Journal of Pharmaceutical Sciences. ,vol. 88, pp. 121- 125 ,(1999) , 10.1021/JS980172I
Anthony L. Zietman, John J. Coen, Katherine C. Dallow, William U. Shipley, The treatment of prostate cancer by conventional radiation therapy: An analysis of long-term outcome International Journal of Radiation Oncology Biology Physics. ,vol. 32, pp. 287- 292 ,(1995) , 10.1016/0360-3016(95)00123-G
Daniel P. Petrylak, Catherine M. Tangen, Maha H.A. Hussain, Primo N. Lara, Jeffrey A. Jones, Mary Ellen Taplin, Patrick A. Burch, Donna Berry, Carol Moinpour, Manish Kohli, Mitchell C. Benson, Eric J. Small, Derek Raghavan, E. David Crawford, Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer The New England Journal of Medicine. ,vol. 351, pp. 1513- 1520 ,(2004) , 10.1056/NEJMOA041318
PATRICK C. WALSH, THEODORE L. DEWEESE, MARIO A. EISENBERGER, A structured debate: immediate versus deferred androgen suppression in prostate cancer-evidence for deferred treatment. The Journal of Urology. ,vol. 166, pp. 508- 516 ,(2001) , 10.1016/S0022-5347(05)65972-1