Chronic haloperidol affects striatal D2-dopamine receptor reappearance after irreversible receptor blockade

摘要: Abstract The time course of recovery [ 3 H]spiperone binding in the rat striatum after administration irreversible antagonist N -ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) was studied chronically haloperidol-treated rats (0.5 mg/kg, i.p., twice a day for two weeks). Chronic neuroleptic treatment significantly enhanced B max value. EEDQ (6.0 i.p.) produced similar profound decrease site density both saline- and rats. However, receptor degradation rate constant animals ( k = 0.0051 h −1 ) production r 1.6 fmol/mg prot/h) were lower than saline-treated 0.0074 ; 1.8 prot/h). These results are different from what is found 6-OH-dopamine lesioned D 2 -receptor (4–5 weeks) denervated Brain Research , 329 (1985) 225–231) while unchanged. Thus, present indicate that chronic haloperidol reduces rates striatal -receptors.