Lack of effect of chronic dopamine receptor blockade on D2 dopamine receptor mRNA level
作者： Hubert H.M. van Tol , Marco Riva , O. Civelli , Ian Creese
DOI: 10.1016/0304-3940(90)90279-I
关键词:
摘要: The chronic treatment of rats with antipsychotic drugs which increase striatal D2 dopamine receptors did not measurably the level receptor mRNA indicating that observed in was primarily due to transcriptional regulation. These and other data suggest molecular mechanisms involved regulation response denervation or neurotransmitter depletion may be different from those occur blockade by antagonist drugs.
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