The role of folates in squamous cell carcinoma of the head and neck.

摘要: Abstract The primary objective of this review is to explore the hypothesis that folate insufficiency may be important in pathogenesis squamous cell carcinomas head and neck (SCCHN) repletion an effective component chemoprevention. main results are disrupts DNA global specific gene methylation patterns such activity certain tumor suppressor genes as p16 possibly p53 lost. Folate pool imbalance impaired repair mechanisms contribute instability strand breaks. Sensitive methods exist for identification individuals with contrast relatively insensitive conventional serum or red assays broad "normal" ranges. impact supplementation can thus quantified. result from alterations cellular uptake by reduced carrier (RFC) and/or receptor (FR) polymorphisms enzymes retention folylpolyglutamate synthetase modification methylene tetrahydrofolate reductase (MTHFR). Known predisposing factors SCCHN alcohol tobacco carcinogens influence balance. reduce secondary risk cancer. Formal studies sufficiency persons at diagnosed treated needed define role prevention these cancers.