Dietary folate is associated with p16INK4A methylation in head and neck squamous cell carcinoma
作者： Kim S. Kraunz , Debra Hsiung , Michael D. McClean , Mei Liu , Joyce Osanyingbemi
DOI: 10.1002/IJC.22013
关键词:
摘要: Inactivation of the p16INK4A (CDKN2A) gene in Rb pathway is among most common somatic alterations observed tobacco-related solid tumors, including head and neck squamous cell carcinoma (HNSCC). In addition, a low folate diet an important risk factor for HNSCC. Decreased dietary animal model hepatocellular has been associated with induction epigenetic silencing gene. ongoing population-based study HNSCC, we sought to extend this observation human disease testing hypothesis that methylation decreased folate. We also investigated association functional polymorphisms metabolism enzyme methylene tetrahydrofolate reductase (MTHFR). 169 HNSCCs, odds ratio those intake was 2.3 (95% CI = 1.1–4.8) when compared high intake. Furthermore, increased at modified by MTHFR alleles previously diminished serum levels. Hence, HNSCC methylation, relationship genotype. Our data provides evidence mechanism action deficiency cancer. © 2006 Wiley-Liss, Inc.
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