Intracranial Carotid Artery Atherosclerosis and the Risk of Stroke in Whites: The Rotterdam Study

摘要: Importance Intracranial atherosclerosis represents a relatively unexplored, but potentially important, cause of stroke in white population. Objective To investigate the relationship between intracranial carotid artery calcification (ICAC) as marker and risk whites. Design, Setting, Participants A population-based cohort study general community with 6 years follow-up was conducted (the Rotterdam Study). Between 2003 2006, random sample 2323 stroke-free persons (mean age, 69.5 years) underwent computed tomography scanning to quantify ICAC volume. All participants were continuously monitored for occurrence until January 1, 2012. Exposure Atherosclerotic internal arteries. Main Outcome Measure Incident stroke. Results During 14 055 person-years follow-up, 91 had stroke, which 74 ischemic. Larger volume related higher independent cardiovascular factors, ultrasound plaque score, other vessels (fully adjusted hazard ratio per an increase 1 SD volume, 1.43 [95% CI, 1.04-1.96]). contributed 75% all strokes; aortic arch extracranial this incidence only 45% 25%, respectively. Conclusions Relevance Our findings establish major factor population suggest that its contribution proportion strokes may be greater than large-artery more proximally located vessel beds.