Pneumococcal conjugate vaccines: a European perspective

摘要: Streptococcus pneumoniae is a leading cause of bacterial pneumonia, meningitis, and acute otitis media in children adults worldwide. In the age group 20% Germany) high mortality (7.5%) pneumococcal meningitis. Furthermore, antibiotic resistance S. increasing Europe, particularly France, Spain, Eastern European countries, whereas Germany Northern Europe are only marginally affected. A 7-valent conjugate vaccine (7vPCV) that was shown to be highly efficacious preventing invasive disease infants USA licensed 2001. It expected broad usage would reduce incidence levels significantly. Important questions have been raised regarding effectiveness this high-risk populations, serotype replacement, efficacy media, co-administration new with other standard childhood vaccines used various countries. France Spain currently most-wide ranging guidelines recommending vaccination for children. Overall, development significant step control Europe. Further progress can from including more than seven serotypes (9-valent, 11-valent).