Administration of Simvastatin after Kainic Acid-Induced Status Epilepticus Restrains Chronic Temporal Lobe Epilepsy
作者： Chuncheng Xie , Jiahang Sun , Weidong Qiao , Dunyue Lu , Lanlan Wei
DOI: 10.1371/JOURNAL.PONE.0024966
关键词:
摘要: In this study, we examined the effect of chronic administration simvastatin immediately after status epilepticus (SE) on rat brain with temporal lobe epilepsy (TLE). First, evaluated cytokines expression at 3 days post KA-lesion in hippocampus and found that simvastatin-treatment suppressed lesion-induced interleukin (IL)-1β tumor necrosis factor-α (TNF-α). Further, quantified reactive astrocytosis using glial fibrillary acidic protein (GFAP) staining neuron loss Nissl 4–6 months KA-lesion. We demonstrated by a significant decrease GFAP-positive cells, attenuated pyramidal neurons CA3 interneurons dentate hilar (DH). next assessed aberrant mossy fiber sprouting (MFS) is known to contribute recurrence spontaneous seizure epileptic brain. contrast robust MFS observed saline-treated animals, extent was restrained rats. Attenuated related decreased neuronal DH, which possibly mechanism underlying hippocampal susceptibility animal treated simvastatin. Electronic encephalography (EEG) recorded during 4 6 The frequency abnormal spikes rats significantly compared saline group. summary, treatment discharges brain, might be due inhibition DH. Our study suggests possible intervention promising strategy for preventing SE exacerbating epilepsy.
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