Simvastatin is the statin that most efficiently protects against kainate-induced excitotoxicity and memory impairment.

摘要: Statins have recently been shown to act as protectants against several neuropathological conditions. They received special attention in the field of Alzheimer's disease (AD), where epidemiological studies indicating a lower prevalence AD/dementia statin-prescribed populations. Excitotoxicity, which derives from overstimulation glutamate receptors, is major cause neuron death neurological diseases, including AD and epilepsy. We carried out comparative study investigate effects all commercially available statins (simvastatin, lovastatin, fluvastatin, pravastatin, atorvastatin) on damage memory impairment. To this end, we studied neurodegeneration mouse model by systemic administration kainate. Simvastatin was most effective statin reducing deleterious caused kainate, severity seizures, excitotoxicity, oxidative damage, neuritic dystrophy apoptosis hippocampus other limbic structures brain cortex. Lovastatin second efficient preventing seizures histopathological signs whilst atorvastatin showed neither antiepileptic nor neuroprotective effects. Only simvastatin enhanced episodic-like memory. best our knowledge first vivo analyze effect statins. Our results suggest that both lovastatin (but especially simvastatin) may well therapeutic potential treatment neurodegenerative diseases involving excitotoxicity impairment, AD.