Inhibitory Effects of Various Beverages on Ritodrine Sulfation by Recombinant Human Sulfotransferase Isoforms SULT1A1 and SULT1A3

摘要: Ritodrine is known to undergo extensive presystemic sulfation in the intestinal mucosa, and its bioavailability as low 30%. Accordingly, inhibition of may lead an increase ritodrine. In this study, we aimed investigate activities ritodrine by SULT1A1, which expressed predominantly liver, SULT1A3, intestine, well inhibitory effects beverages on their activities. We investigated using recombinant human sulfotransferase (SULT) 1A1 SULT1A3 vitro study. Next, grapefruit juice, orange green tea, black tea sulfation. Sulfation was much higher than that suggesting be limited SULT1A3. The SULT1A1 were significantly inhibited all examined at a concentration 10%. Green exhibited potent inhibition; even 5%, they both 100% ≥95%. Our results suggest concomitant ingestion such orally administered ritodrine, perhaps other β2-agonists, clinical or adverse reactions.