Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Kidney Injury Molecule 1 (KIM-1) as Predictors of Incident CKD Stage 3: The Atherosclerosis Risk in Communities (ARIC) Study

摘要: Background Identifying individuals at risk of chronic kidney disease (CKD) is critical for timely treatment initiation to slow progression the disease. Neutrophil gelatinase-associated lipocalin (NGAL) and injury molecule 1 (KIM-1) are known biomarkers acute injury, but it unknown whether these markers associated with incident CKD stage 3 in general population. Study Design Matched case-control study. Setting & Participants African American white participants from Atherosclerosis Risk Communities (ARIC) who baseline had an estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m 2 urinary albumin-creatinine ratio ≤30 mg/g. 143 controls were matched age, sex, race cases after 8.6 years follow-up. Predictors Quartile NGAL KIM-1. Outcomes Measurements Incident (eGFR follow-up a decrease eGFR ≥25%). Results Both ( P = 0.05) KIM-1 levels -trend 0.03). Adjustment creatinine albumin resulted nonsignificant association (highest quartile adjusted OR, 1.52; 95% CI, 0.64-3.58; 0.2). No significant between level was observed crude or models. Limitations The relatively small sample size study limits precision power detect weak associations. Conclusions Higher NGAL, not KIM-1, 3. concentration attenuated this association. Additional studies needed confirm findings assess utility as marker risk.