Vitamin C and the risk of developing inflammatory polyarthritis: prospective nested case-control study

摘要: Objective: To investigate whether, there is an association between consumption of fruit and vegetables dietary antioxidants the risk developing inflammatory polyarthritis (IP). Methods: In a prospective, population based, nested case-control study residents Norfolk, UK, men women aged 45–74 years were recruited, 1993 1997 through general practice age-sex registers to Norfolk arm European Prospective Investigation Cancer (EPIC-Norfolk). Dietary intake was assessed at baseline using 7 day diet diaries. Seventy three participants who went on develop IP 2001 registered by Arthritis Register (NOAR) identified. Incident cases IP, practitioners, fulfilled criteria two or more swollen joints, persisting for minimum 4 weeks. Each case matched age sex with controls free IP. Results: Lower intakes vegetables, vitamin C associated increased Those in lowest category intake, compared highest, their than threefold, adjusted odds ratio (OR) 95% confidence intervals (CI) 3.3 (95% CI 1.4 7.9). Weak inverse associations E s-carotene found. Conclusion: Patients (cases) consumed less controls, which appeared increase The mechanism this effect uncertain. Thus similar studies are necessary confirm these results.