Bone morphogenetic protein 2 promotes primordial follicle formation in the ovary
作者： Prabuddha Chakraborty , Shyamal K. Roy
DOI: 10.1038/SREP12664
关键词:
摘要: Primordial follicles (PF) are formed when somatic cells differentiate into flattened pregranulosa cells, invaginate the oocyte nests and encircle individual oocytes. We hypothesize that BMP2 regulates PF formation by promoting transition of germ oocytes cells. E15 hamster ovaries were cultured for 8 days corresponding to postnatal day (P8) in vivo, with or without BMP2, was examined. expressed as well ovarian during development. exposure first two last entire culture led increase suggesting affected both cell differentiation. Whereas an ALK2/3 inhibitor completely blocked BMP2-induced formation, ALK2-specific partially effective, via ALK2 ALK3. also reduced apoptosis vitro. Further, more meiotic present exposed ovaries. In summary, results provide evidence primordial follicle pre-granulosa it acts
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