Retinal microvasculature in Alzheimer's disease.

摘要: Although cerebral small vessel disease has been implicated in the development of Alzheimer's (AD), microcirculation is difficult to visualize directly vivo. As retina and brain share similar embryological origin, anatomical features physiological properties with vessels, retinal vessels thus offer a unique easily accessible "window" study correlates consequences diseases Retinal microvasculature can now be visualized, quantified monitored non-invasively using state-of-the-art imaging technology. Recent clinic- population-based studies have demonstrated link between vascular changes dementia, particular AD, disease. In this review, we summarize current findings on such as retinopathy signs novel network parameters caliber cognitive dysfunction disease, discuss possible future research further evaluate whether might help elucidate mechanisms contributing AD provide additional value predicting who may at risk developing AD.