Retinal microvascular signs and 10-year risk of cerebral atrophy: the Atherosclerosis Risk in Communities (ARIC) study.

摘要: Background and Purpose— Cerebral atrophy, detected as ventricular enlargement or sulcal widening on MRI, is recognized a risk factor for vascular dementia Alzheimer disease. However, its underlying pathophysiology not known. We examined whether retinal microvascular assessment could provide predictive information the of MRI. Methods— A prospective, population-based study was conducted 810 middle-aged persons without clinical stroke MRI infarcts. All participants had first cranial photography in 1993 to 1995 returned repeated 2004 2006 (median follow-up 10.5 years). Retinal photographs were graded presence retinopathy abnormalities, images size according standardized protocols. Ventricular defined an increase ≥3 10 grades between b...