Fibrogenesis in alcoholic liver disease

摘要: Alcoholic liver disease (ALD) is a major cause of morbidity and mortality worldwide. In developed countries, ALD end-stage that requires transplantation. The spectrum includes simple steatosis, alcoholic hepatitis, fibrosis, cirrhosis, hepatocellular carcinoma. Alcohol abstinence the most effective therapy for ALD. However, targeted therapies are urgently needed patients with severe (i.e., hepatitis) or those who do not abstain from alcohol. lack studies availability animal models reflect all features this in humans inhibit development new drugs ALD-associated fibrosis, hepatic stellate cells principal cell type responsible extracellular matrix production. Although mechanisms underlying fibrosis largely similar to observed other chronic diseases, oxidative stress, methionine metabolism abnormalities, hepatocyte apoptosis, endotoxin lipopolysaccharides activate Kupffer may play unique roles disease-related fibrogenesis. Lipogenesis during early stages has recently been implicated as risk factor progression cirrhosis. Other topics include osteopontin, interleukin-1 signaling, genetic polymorphism. review, we discuss basic pathogenesis focus on