Application of iPS cell technology to cancer epigenome study: Uncovering the mechanism of cell status conversion for drug resistance in tumor

摘要: Recent studies imply that cancer cells possess the ability to reversibly change their properties between a drug sensitive state and resistant accompanied by epigenetic changes. This evidence indicates better understanding of epigenetics is important for efficient therapies. Nevertheless, it had been difficult deeply examine mechanisms because lack tools actively modify coordinated events. In this stagnant situation, reprogramming technology established Yamanaka coworkers have shed new light. The novel has made possible researchers artificially introduce remodeling into somatic cells. Accordingly, we might be able use as tool reorganization. In review, idea cell interconversion in attributable altered regulations. We then depict modifications observed during process give some examples difficulty reprogramming. Finally, discuss how can translate refractoriness uncovering unique regulations cells, which applicable eventually development therapeutics against