Systematic Screening for Mutant Mouse Lines with Defects in Body Temperature Regulation
作者： M. Willershäuser , N. Ehrhardt , R. Elvert , E. K. Wirth , U. Schweizer
DOI: 10.1007/978-3-642-28678-0_40
关键词:
摘要: Spontaneous daily torpor as well cold- and fasting-induced is observed in many mammals birds. The frequency intensity of are largely influenced by characterized environmental conditions. inherited component phenotypic variation body temperature regulation is, however, only poorly understood. identification mutations affecting physiological may elucidate novel molecular mechanisms contributing to metabo- thermoregulatory behavior. Therefore, we monitored rectal (T b) six inbred mouse strains (129/SvJ, AKR/J, C57BL/6J, C57BL/6N, Balb/cJ, SWR/J) 146 mutant lines age-matched controls. Measurements were taken under ad libitum conditions response either food restriction or deprivation. Inbred mice showed considerable strain-specific differences T b feeding after was on average ≈0.4°C higher females compared males all lines. reflected a trade-off between changes mass with the least loss exhibiting largest drop b. In 36 out significantly (15 lines) lower (21 deprivation, 13 augmented reduction found two which than 31°C. conclusion, deprivation an important indicator for genotype-related systemic functions. Depending test 25–32% significant alterations
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