Parvalbumin-immunoreactive neurons in the hippocampal formation of Alzheimer's diseased brain

摘要: The number and topographic distribution of immunocytochemically stained parvalbumin interneurons was determined in the hippocampal formation control Alzheimer's diseased brain. In hippocampus, were aspiny pleomorphic, with extensive dendritic arbors. dentate gyrus, cells, as well a dense plexus fibers puncta, associated granule cell layer. A few cells also occupied molecular strata oriens pyramidale CA1-CA3 subfields, neurons gave rise to dendrites that extended into adjacent strata. Densely puncta beaded stratum pyramidale, less staining radiatum. Virtually no profiles observed lacunosum-moleculare or alveus. Numerous polymorphic characterized deep layer subiculum lamina principalis externa presubiculum. there an approximate 60% decrease gyrus/CA4 subfield (P<0.01) subfields CA1-CA2 (P<0.01). contrast, did not statistically decline CA3, presubiculum brains relative controls. Concurrent Thioflavin-S histochemistry reveal degenerative changes within parvalbumin-stained profiles. These findings specific are selectively vulnerable disease. This vulnerability may be related their differential connectivity, e.g., those regions connectionally cerebral cortex (dentate gyrus CA1) more than subcortical loci (subiculum presubiculum).