Human Papillomavirus in Head and Neck Squamous Cell Carcinomas in Nonsmokers
作者： P. Fouret , G. Monceaux , S. Temam , L. Lacourreye , J. L. Guily
DOI: 10.1001/ARCHOTOL.1997.01900050063008
关键词:
摘要: Objective: To establish relationships between smoking status and human papillomavirus in head neck squamous cell carcinomas. Design: Human was detected paraffin-embedded samples using E6-directed consensus primers type-specific oligonucleotide probes. Patients were classified as smokers nonsmokers. Alcohol use also recorded. Data analyzed by means of the Fisher exact test. Sequence analysis exons 5 to 8 p53 gene performed tumor from Setting: Academic medical center Paris, France. Patients: One hundred eighty-seven consecutive patients with carcinoma. Results: The overall prevalence papillomaviral infection 10.7%. occurred more frequently ( P =.02) oropharyngeal carcinoma (18.6%) than other locations (6.1%). There 10 nonsmokers (5%). 50% incidence (95% confidence interval, 19%-81%) differed significantly 8.5% 5%-14%; =.003). No occupational risk factor recorded None these had mutations cancer cells. Conclusion: These findings suggest that may play a role carcinomas Arch Otolaryngol Head Neck Surg. 1997;123:513-516
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