Imaging Mass Spectrometric Analysis of Neurotransmitters: A Review.
作者： Gustavo A. Romero-Perez , Shiro Takei , Ikuko Yao
DOI: 10.5702/MASSSPECTROMETRY.S0049
关键词:
摘要: Imaging mass spectrometry (IMS) is a toolbox of versatile techniques that enable us to investigate analytes in samples at molecular level. In recent years, IMS, and especially matrix-assisted laser desorption/ionisation (MALDI), has been used visualise wide range metabolites biological samples. Simultaneous visualisation the spatial distribution single sample with little tissue disruption can be considered as one important advantage MALDI over other techniques. However, several technical hurdles including low concentrations rapid degradation rates small molecule metabolites, matrix interference signals poor ionisation, need addressed before reliable tool for analysis such neurotransmitters brain tissues from different sources humans. present review we will briefly describe current IMS study discuss their status, challenges, well future prospects.
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