Catabolism of the apolipoproteins of HDL in control and nephrotic rats.

摘要: Abstract 125I-labeled high density lipoprotein (HDL) from control rats, or rats made nephrotic by puromycin amino-nucleoside, was injected into rats. At 5 and 20 h, the amount distribution of label remaining in apolipoproteins HDL, A-I, E, A-IV C measured after ultracentrifugal isolation HDL SDS-polyacrylamide gel electrophoretic separation each apolipoprotein. There were no significant differences removal rates apolipoprotein individual when controls compared to nephrotics. contains less than 10% either E content indicating that neither nor play a role determining catabolic fate rat HDL. In severely animals reduced 50% values A-I rose 87% total The nephrotics catabolized at same irrespective degree nephrosis altered composition. apparent fractional for apolipoproteins, determined did not differ one another, all half normal controls. These results support concept is as particle mediated recognition, they reinforce earlier work increased synthesis dominant factor responsible plasma concentrations experimental nephrosis.