Defective lipolysis persists in hearts of rats with heymann nephritis in the absence of nephrotic plasma.
作者： George A. Kaysen , X-M. Pan , William G. Couser , Ilona Staprans
DOI: 10.1016/S0272-6386(12)70178-6
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摘要: Catabolism of trig lyceride-rich lipoproteins, including chylomicrons (CM), is reduced in the nephrotic syndrome. It has been suggested that hyperlipidemia per se might lead to CM catabolism by saturating catabolic sites. Evidence also implicates disordered high-density lipoprotein function as reducing activity lipase (LPL), final effector lipolysis. To establish whether lipolysis would be abnormal absence either rat lipoproteins or hyperlipidemia, we measured isolated perfused hearts rats with passive Heymann nephritis. We found was significantly 30% at 30 minutes (246 ± 40 μmol v 164 10 fatty acid released/hr, P 210.6 25.9 free released/hr/g heart, 19.4 11.7 released/hr/heart,
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