Inhibition of acute lung inflammation and injury is a target of brain cooling after heatstroke injury.

摘要: Background: Although brain cooling has recently been reported as effective in improving the survival after heatstroke generation rats, mechanisms underlying therapeutic effects of are not fully elucidated. This study was conducted to test whether acute lung inflammation and damage that might occur during could be affected by cooling. Methods: Anesthetized rats were randomized into four groups follows: (a) normothermic controls (n = 8); (b) without saline delivery (c) treated with 36°C via retrograde jugular vein (d) 4°C 8). Heatstroke induced putting animals a folded heating pad 42°C for 68 minutes controlled circulating hot water. The core temperatures maintained at about 36°C. cardiovascular parameters monitored all experiments. Bronchoalveolar lavage (BAL) done left 20 termination heat stress determination cellular ischemia markers (e.g., glutamate, lactate-to-pyruvate ratio), proinflammatory cytokines (interleukin-1, tumor necrosis factor-alpha), nitric oxide metabolites. Parts right excised meloperoxidase measurement, whereas rest collected score assessments. Results: When compared those controls, untreated or saline-treated had higher values BAL fluid levels markers, cytokines, metabolites, meroperoxidase activity, score, neutrophil infiltration. Brain causes infusion significantly reduced heat-induced increased Conclusions: These experimental data indicate is target injury.