Heatstroke model for desert dry-heat environment and observed organ damage

摘要: Abstract Background Heatstroke is one of the most common clinical emergencies. that occurred in a dry-heat environment such as desert usually more seriously effective and often leads to death. However, report pathophysiologic mechanisms about heatstroke has not been seen. Objectives Our objectives are establish rat model desert, assess different degrees damage organ, preliminarily discuss mechanism desert. Methods The first step, we have established dry heat second accessed changes morphology blood indicators rats Results expressed changing characteristics mean arterial pressure, core temperature, heart rate. organ changed from mild serious level, specifically enzymology parameters alanine aminotransferase, aspartate creatinine, urea, uric acid, creatine kinase-MB, kinase, gas base excess extracellular fluid bicarbonate ions (HCO 3 −). Conclusions We successfully identified presented on physiological varying damage, which aggravated by evolution discussed