Effects of combination treatment with dexamethasone and mannitol on neuronal damage and survival in experimental heat stroke.

摘要: There is evidence that increased plasma cytokines, elevated brain levels of monoamines and hydroxyl radical production may be implicated in pathogenesis during heat stroke rats. Acute treatment with a combined therapeutic approach has been repeatedly advocated cerebral ischemia experiments. The aim this study was to investigate whether the agent (mannitol dexamethasone) beneficial efficacy improve survival time (ST) stroke-induced damage experimental stroke. Urethane-anesthetized rats underwent instrumentation for measurement colonic temperature, mean arterial pressure (MAP), striatal blood flow (CBF), heart rate, neuronal score. were exposed an ambient temperature (43 °C) induce Concentrations ischemic markers, dopamine, serotonin, corpus striatum, tumor necrosis factor-α (TNF-α) observed After onset stroke, display decreased MAP, CBF, TNF-α, release, severe compared those normothermic control However, immediate confers significant protection against hypotension, systemic inflammation, ischemia, overloads, improves ST Our data suggest administration seems have more effective ameliorate prolong ST.