Association between microstructural integrity of frontostriatal tracts and school functioning: ADHD symptoms and executive function as mediators.

摘要: Background Deficits in executive function (EF), impaired school functioning and altered white matter integrity frontostriatal networks have been associated with attention-deficit/hyperactivity disorder (ADHD). However, relationships between impairments these areas are unclear. Using a sample of youths without ADHD, this study examined the association microstructural tracts dysfunction mediating roles EF ADHD symptoms association. Method The included 32 Taiwanese age-, sex-, handedness- IQ-matched typically-developing (TD) youths. Participants were assessed using psychiatric interviews, parent reports on functioning, measures from Cambridge Neuropsychological Test Automated Battery (CANTAB). reconstructed by diffusion spectrum imaging (DSI) tractography subdivided into four functionally distinct segments: caudate–dorsolateral, caudate–medial prefrontal, caudate–orbitofrontal caudate–ventrolateral tracts. Results Youths relative to TD youths, showed all bilateral pairs (decreased general fractional anisotropy, GFA), had poor attention, vigilance response inhibition, functioning. Altered was significantly dysfunction, which mediated attention/vigilance inhibition addition inattention hyperactivity symptoms. Conclusions Our findings demonstrate an suggest that deficits may be mechanisms for Future research is needed test directionality specificity finding.