Coronavirus infection of the central nervous system: host–virus stand-off
作者： Cornelia C. Bergmann , Thomas E. Lane , Stephen A. Stohlman
DOI: 10.1038/NRMICRO1343
关键词:
摘要: Several viruses infect the mammalian central nervous system (CNS), some with devastating consequences, others resulting in chronic or persistent infections associated little no overt pathology. Coronavirus infection of murine CNS illustrates contributions both innate immune response and specific host effector mechanisms that control virus replication distinct cell types. Despite T-cell-mediated acute infection, regulatory mechanisms, probably designed to protect integrity, contribute failure eliminate virus. Distinct from cytolytic expressed during non-lytic humoral immunity prevails suppressing infectious persistence.
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