Expression of Mig (Monokine Induced by Interferon-γ) Is Important in T Lymphocyte Recruitment and Host Defense Following Viral Infection of the Central Nervous System
作者： Michael T. Liu , David Armstrong , Thomas A. Hamilton , Thomas E. Lane
DOI: 10.4049/JIMMUNOL.166.3.1790
关键词:
摘要: Induction of a Th1 immune response against viral infection the CNS is important in contributing to clearance. The present studies demonstrate role for T cell chemoattractant chemokine Mig (monokine induced by IFN-γ) mouse hepatitis virus CNS. Analysis kinetics expression revealed mRNA transcripts at days 7 and 12 postinfection (p.i.) but not early (day 2) or late 35) infection. To determine functional significance, virus-infected mice were treated with anti-Mig antisera, severity disease was evaluated. Such treatment resulted marked increase mortality that correlated >3 log burden within brains as compared control normal rabbit serum. Anti-Mig-treated displayed significant decrease ( p + CD8 recruitment into serum-treated mice. In addition,
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