Cytokine and chemokine networks: pathways to antiviral defense.

摘要: The complex interplays between cytokines and chemokines are emerging as key communication signals in the shaping of innate adaptive immune responses against foreign pathogens, including viruses. In particular, virus-induced expression cytokine chemokine profiles drives recruitment activation effector cells to sites tissue infection. Under conditions infection with murine cytomegalovirus (MCMV), a herpesvirus pathogenic potential, early functions essential control virus replication pathology. coordinated MCMV-induced promote effective natural killer (NK) cell function, ultimately MCMV clearance. studies highlighted this chapter illustrate vivo pathways mediated by regulating that vital for localized antiviral defenses.