Peripheral Blood Cytokine Profiling During Pregnancy and Post-partum Periods

摘要: Citation Kraus TA, Sperling RS, Engel SM, Lo Y, Kellerman L, Singh T, Loubeau M, Ge Garrido JL, Rodriguez-Garcia Moran TM. Peripheral blood cytokine profiling during pregnancy and post-partum periods. Am J Reprod Immunol 2010; 64: 411–426 Problem  Pregnancy requires that the maternal immune system adapt to prevent rejection of fetal semi-allograft. This immunologic adaptation may contribute pregnancy-related alterations in disease susceptibility severity infections from viral pathogens such as influenza virus. Method Study  As part a larger study investigating systemic response pregnancy, peripheral was collected three times twice measure serum levels 23 cytokines, chemokines, growth factors. longitudinal design allowed each woman’s draw serve her own comparison, thus controlling for interpersonal variability expression levels. Results  When compared samples, significant changes IFNγ, TNFα, VEGF, GCSF, Eotaxin, MCP-1 were observed. These have effects vivo culture. Conclusion  Pregnancy-associated steady state cytokines important consequence.