Plasma morphine concentrations during chronic oral administration in patients with cancer pain

摘要: Abstract Plasma concentrations of morphine were studied in 16 patients with chronic pain due to advanced cancer, treated regular doses chloride by the oral route. Doses ranged from 20 125 mg every 4 h and a significant, positive, linear correlation was found between dose (range 0.22–3.01 mg/kg) mean plasma concentration 22–364 ng/ml). The profile curve is described be subject considerable, individual variation. present investigation supports experience that good relief can obtained, if requirements as interval are taken into consideration.