Hla-restricted, peptide-specific antigen binding proteins

摘要: Antigen binding proteins with TCR-like paratopes, that is, an antigen region specific for HLA-A2 restricted peptide are disclosed. The encompass antibodies in a variety of forms, including full-length antibodies, substantially intact Fab fragments, F(ab')2 and single chain Fv fragments. Fusion proteins, such as scFv fusions immunoglobulin or T-cell receptor domains, incorporating the specificity each also contemplated by invention. Furthermore, immunoconjugates may include to which is linked radioisotope, fluorescent other detectable marker, cytotoxin, molecule encompassed Among things, can be used delivery agent elicit therapeutic effect facilitate immune effector function.