Home intravenous antibiotics for cystic fibrosis.

摘要: BACKGROUND Recurrent endobronchial infection in cystic fibrosis requires treatment with intravenous antibiotics for several weeks, which is usually administered hospital, affecting health costs and quality of life patients their families. It not known whether receiving at home have better or equivalent outcomes, if are reduced it preferred than in-hospital treatment. Home training to carers needs a few previous days hospital. OBJECTIVES To determine antibiotic therapy as effective in-patient by and/or SEARCH STRATEGY References trials were obtained from the specialist register held editorial base Cochrane Cystic Fibrosis Genetic Disorders Group. Handsearching abstracts books all Spanish Conferences on last European Conference (Stockholm, 2000) was carried out authors. SELECTION CRITERIA Randomised controlled where compared treatment, including adults children fibrosis. All kinds regimens included. DATA COLLECTION AND ANALYSIS Three reviewers independently selected be included review, assessed methodological each trial extracted data using standardised form. Because limitations, narrative synthesis used this stage. MAIN RESULTS One study 17 aged 10 41 years an infective exacerbation Pseudomonas aeruginosa. 31 admissions analysed independent events. Outcomes measured 21 follow-up after initiation had fewer investigations performed hospital (p<0.002) general activity higher group. No differences found clinical adverse events, complications lines line changes time next admission. received less low-dose maintenance antibiotic. Quality measures showed no dyspnoea emotional state, but fatigue mastery worse patients, possibly due need support. Personal, family, sleeping eating disruptions important admissions. cheaper families Indirect determined. REVIEWER'S CONCLUSIONS The current evidence restricted one small study. suggests that short term does harm reduces social disruptions. decision attempt should based individual basis appropriate local resources. More research urgently required.