Pseudomonas aeruginosa Biofilm Formation in the CF Lung and Its Implications for Therapy

摘要: Numerous microorganisms colonize or are associated with the airways of individuals Cystic Fibrosis (CF). Impairment mucociliary clearance in CF lungs leads to a greater number microbes present for simple fact that they not physically removed (Gibson, Burns et al. 2003; Boucher 2004). Microbes thrive large mucus plugs airways, probably due optimal growth temperatures and abundance nutrients. Additionally, patients display defective antimicrobial peptide activity their lungs, which can further enhance microbial colonization As result these abnormalities, extraordinarily susceptible infection bacteria, fungi, viruses, including Pseudomonas aeruginosa, Staphylococcus aureus, Burkholderia cepacia complex, Stenotrophomonas maltophilia, Haemophilus influenzae, Aspergillus fumigatus, Candida albicans, Respiratory Syncytial virus, Influenza Virus (Govan Deretic 1996; Lyczak, Cannon 2002; Saiman Siegel 2004; Lipuma 2010). The relative rate isolation various varies over time. For instance, early life, S. aureus is most often isolated microbe, but by adolescence young adulthood, P. aeruginosa becomes predominate microorganism from Pressler, Bohmova 2011).