Chapter 22. Relationships in the Structure and Function of Cell Surface Receptors for Glycoprotein Hormones, Bacterial Toxins, and Interferon

摘要: Publisher Summary There is a structural and functional relationship in the mechanism by which glycoprotein hormones thyrotropin (TSH), luteinizing hormone (LH), human chorionic gonadotropin (hCG), follicle-stimulating (FSH)], certain bacterial toxin, antiviral protective agent, interferon transmit their message through cell membrane. The change membrane state expresses itself as different exposure of surface determinants, including those important receptors for other effectors function electrochemical gradient across Gangliosides are family glycolipids whose nomenclature derived from length oligosaccharide-core structure. Ganglioside confers or toxin specificity its oligosaccharide determinant. A protein cholera toxins, carries information on primary sequence necessary stimulation adenylate cyclase system. TSH receptor defect rat thyroid tumor has been correlated with an alteration ganglioside content membranes this biosynthetic enzymes concerned synthesis higher order gangliosides implicate components GM1 induces conformational that cannot be duplicated interacts plasma membranes. These interactions affect ability both to bind stimulate activity