Structure and Regulated Expression of the TSH Receptor Gene: Differences and Similarities to Gonadotropin Receptors
作者： Motoyasu Saji , Shoichiro Ikuyama , Hiroki Shimura , Toshiaki Ban , Shinji Kosugi
DOI: 10.1007/978-1-4613-8386-4_16
关键词:
摘要: Glycoprotein hormones—lutropin/chorionic gonadotropin (LH/CG), follicle stimulating hormone (FSH), and thyrotropin (TSH)—have a high degree of primary tertiary structure similarity, yet are target tissue specific (1–5). The structural similarities the hormones complemented by functional Thus, all well recognized to activate cAMP signal transducing system, modulate both growth differentiation their respective tissues. It is increasingly evident, in addition, that depend on action other hormones, such as insulin insulin-like factor I (IGF-I), regulate differentiated function (6–8).
springer.com
springerlink.com参考文章(138)
G. F. Fenzi, P. Vitti, C. Marcocci, L. Chiovato, E. Macchia, TSH Receptor Autoantibodies Affecting Thyroid Cell Function Springer US. pp. 83- 90 ,(1987) , 10.1007/978-1-4613-0945-1_10
T. Braun, P.R. Schofield, R. Sprengel, Amino−terminal leucine−rich repeats in gonadotropin receptors determine hormone selectivity The EMBO Journal. ,vol. 10, pp. 1885- 1890 ,(1991) , 10.1002/J.1460-2075.1991.TB07714.X
G D Chazenbalk, Y Nagayama, D Russo, H L Wadsworth, B Rapoport, Functional analysis of the cytoplasmic domains of the human thyrotropin receptor by site-directed mutagenesis. Journal of Biological Chemistry. ,vol. 265, pp. 20970- 20975 ,(1990) , 10.1016/S0021-9258(17)45312-9
S. Guazzi, M. Price, M. De Felice, G. Damante, M. G. Mattei, R. Di Lauro, Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding specificity. The EMBO Journal. ,vol. 9, pp. 3631- 3639 ,(1990) , 10.1002/J.1460-2075.1990.TB07574.X
R. A. Dixon, I. S. Sigal, M. R. Candelore, R. B. Register, W. Scattergood, E. Rands, C. D. Strader, Structural features required for ligand binding to the beta-adrenergic receptor. The EMBO Journal. ,vol. 6, pp. 3269- 3275 ,(1987) , 10.1002/J.1460-2075.1987.TB02645.X
Leonard D. Kohn, Chapter 22. Relationships in the Structure and Function of Cell Surface Receptors for Glycoprotein Hormones, Bacterial Toxins, and Interferon Annual Reports in Medicinal Chemistry. ,vol. 12, pp. 211- 222 ,(1977) , 10.1016/S0065-7743(08)61561-4
RL Tate, HI Schwartz, JM Holmes, LD Kohn, Thyrotropin receptors in thyroid plasma membranes. Characteristics of thyrotropin binding and solubilization of thyrotropin receptor activity by tryptic digestion. Journal of Biological Chemistry. ,vol. 250, pp. 6509- 6515 ,(1975) , 10.1016/S0021-9258(19)41094-6
D. Civitareale, R. Lonigro, A.J. Sinclair, R. Di Lauro, A thyroid-specific nuclear protein essential for tissue-specific expression of the thyroglobulin promoter. The EMBO Journal. ,vol. 8, pp. 2537- 2542 ,(1989) , 10.1002/J.1460-2075.1989.TB08391.X
C.H. Tsai-Morris, E. Buczko, W. Wang, X.Z. Xie, M.L. Dufau, Structural organization of the rat luteinizing hormone (LH) receptor gene. Journal of Biological Chemistry. ,vol. 266, pp. 11355- 11359 ,(1991) , 10.1016/S0021-9258(18)99170-2
R.S. Schwartz, N.R. Rose, Autoimmunity: Experimental and Clinical Aspects ,(1986)