Inhibitory effect of zinc on the advanced glycation end product-induced apoptosis of mouse osteoblastic cells
作者： MINGYUE XIONG , LIQIANG LIU , ZHENHUI LIU , HANGFEI GAO
关键词:
摘要: Osteoporosis and diabetes have become serious health problems worldwide. Previous studies suggested that is associated with osteoporosis increased fracture risk. However, the mechanism underlying diabetes‑induced remains to be elucidated. Therefore, present study aimed examine osteoporosis, determine protective effects of zinc, which known closely diabetes. The results demonstrated zinc inhibited advanced glycation end product (AGE)‑induced MC3T3‑E1 cell apoptosis by attenuating production reactive oxygen species, inhibiting caspase‑3 caspase‑9 activation, release cytochrome c from between mitochondria cytosol. Furthermore, was found protect cells against AGE‑induced via mitogen‑activated protein kinase/extracellular signal‑regulated kinase phosphoinositide 3‑kinase/AKT signaling pathways. In conclusion, these findings enable a better understanding may indicate novel target for its prevention treatment.
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