Origin of globins and a mystery of myoglobin codon root symmetry
作者： Nora Ieviña , Gunårs Chipens
DOI:
关键词:
摘要: The amino acid sequence 49-94 of myoglobin involved in heam binding has 74 % symmetric codon roots – the second letters. search for reason symmetry revealed that ancestor globin genes was not formed by exon shuffl ing, but multiplication a 21-membered nucleotide and it regular polynucleotide. repeat unit pile contemporary root posesses an inversion centre indicating evolved after origin gene. Its cause possible biological functions is mystery. A model coding gene suggested to be identical units separated 23 introns.
lu.lv 参考文章(12)
Nora Ievina, Gunars Chipens, A new approach to study the origin of genes and introns ,(2003)
Dr.C.R. Beddell, G.C. Sheppey, T.L. Blundell, K. Sasaki, S. Dockerill, P.J. Goodford, SYMMETRICAL FEATURES IN POLYPEPTIDE HORMONE-RECEPTOR INTERACTIONS International Journal of Peptide and Protein Research. ,vol. 9, pp. 161- 165 ,(2009) , 10.1111/J.1399-3011.1977.TB03476.X
Michael Sjöström, Svante Wold, A multivariate study of the relationship between the genetic code and the physical-chemical properties of amino acids. Journal of Molecular Evolution. ,vol. 22, pp. 272- 277 ,(1985) , 10.1007/BF02099756
R. Dorit, L Schoenbach, W Gilbert, How big is the universe of exons Science. ,vol. 250, pp. 1377- 1382 ,(1990) , 10.1126/SCIENCE.2255907
S. R. PELC, Correlation between Coding-Triplets and Amino-Acids Nature. ,vol. 207, pp. 597- 599 ,(1965) , 10.1038/207597A0
J. C. KENDREW, R. E. DICKERSON, B. E. STRANDBERG, R. G. HART, D. R. DAVIES, D. C. PHILLIPS, V. C. SHORE, Structure of Myoglobin: A Three-Dimensional Fourier Synthesis at 2 Å. Resolution Nature. ,vol. 185, pp. 422- 427 ,(1960) , 10.1038/185422A0
Thomas Hankeln, Heike Friedl, Ingo Ebersberger, Jon Martin, Erwin R. Schmidt, A variable intron distribution in globin genes of Chironomus: evidence for recent intron gain. Gene. ,vol. 205, pp. 151- 160 ,(1997) , 10.1016/S0378-1119(97)00518-0
R. C. Hardison, A brief history of hemoglobins: plant, animal, protist, and bacteria. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 5675- 5679 ,(1996) , 10.1073/PNAS.93.12.5675
F Crick, Split Genes and RNA Splicing Science. ,vol. 204, pp. 264- 271 ,(1979) , 10.1126/SCIENCE.373120
A Stoltzfus, D. Spencer, M Zuker, J. Logsdon, W. Doolittle, Testing the exon theory of genes: the evidence from protein structure. Science. ,vol. 265, pp. 202- 207 ,(1994) , 10.1126/SCIENCE.8023140