How big is the universe of exons
作者： R. Dorit , L Schoenbach , W Gilbert
关键词:
摘要: If genes have been assembled from exon subunits, the frequency with which exons are reused leads to an estimate of size underlying universe. An database was constructed available protein sequences, and homologous were identified on basis amino acid identity; statistically significant matches determined by Monte Carlo methods. It is estimated that only 1000 7000 needed construct all proteins.
sciencemag.org
harvard.edu参考文章(52)
Tim Hunkapiller, Leroy Hood, Diversity of the immunoglobulin gene superfamily. Advances in Immunology. ,vol. 44, pp. 1- 63 ,(1989) , 10.1016/S0065-2776(08)60639-2
P P Minghetti, D E Ruffner, W J Kuang, O E Dennison, J W Hawkins, W G Beattie, A Dugaiczyk, Molecular structure of the human albumin gene is revealed by nucleotide sequence within q11-22 of chromosome 4. Journal of Biological Chemistry. ,vol. 261, pp. 6747- 6757 ,(1986) , 10.1016/S0021-9258(19)62680-3
Chiao-Chain Huang, Charlotte Hammond, J.Michael Bishop, Nucleotide sequence and topography of chicken c-fps: Genesis of a retroviral oncogene encoding a tyrosine-specific protein kinase☆ Journal of Molecular Biology. ,vol. 181, pp. 175- 186 ,(1985) , 10.1016/0022-2836(85)90083-X
G H Swift, C S Craik, S J Stary, C Quinto, R G Lahaie, W J Rutter, R J MacDonald, Structure of the two related elastase genes expressed in the rat pancreas. Journal of Biological Chemistry. ,vol. 259, pp. 14271- 14278 ,(1984) , 10.1016/S0021-9258(18)89888-X
D E Cool, R T MacGillivray, Characterization of the human blood coagulation factor XII gene. Intron/exon gene organization and analysis of the 5'-flanking region. Journal of Biological Chemistry. ,vol. 262, pp. 13662- 13673 ,(1987) , 10.1016/S0021-9258(19)76478-3
J. Parma, D. Christophe, V. Pohl, G. Vassart, Structural organization of the 5' region of the thyroglobulin gene. Evidence for intron loss and "exonization" during evolution. Journal of Molecular Biology. ,vol. 196, pp. 769- 779 ,(1987) , 10.1016/0022-2836(87)90403-7
K. Drickamer, V. McCreary, Exon structure of a mannose-binding protein gene reflects its evolutionary relationship to the asialoglycoprotein receptor and nonfibrillar collagens. Journal of Biological Chemistry. ,vol. 262, pp. 2582- 2589 ,(1987) , 10.1016/S0021-9258(18)61545-5
T M Krieg, M P Schafer, C K Cheng, D Filpula, P Flaherty, P M Steinert, D R Roop, Organization of a type I keratin gene. Evidence for evolution of intermediate filaments from a common ancestral gene. Journal of Biological Chemistry. ,vol. 260, pp. 5867- 5870 ,(1985) , 10.1016/S0021-9258(18)88905-0
Kenshi Obaru, Teruhisa Tsuzuki, Chiaki Setoyama, Kazunori Shimada, Structural organization of the mouse aspartate aminotransferase isoenzyme genes. Introns antedate the divergence of cytosolic and mitochondrial isoenzyme genes. Journal of Molecular Biology. ,vol. 200, pp. 13- 22 ,(1988) , 10.1016/0022-2836(88)90329-4
M E Taylor, P M Brickell, R K Craig, J A Summerfield, Structure and evolutionary origin of the gene encoding a human serum mannose-binding protein. Biochemical Journal. ,vol. 262, pp. 763- 771 ,(1989) , 10.1042/BJ2620763