A spoonful of DHAP keeps mTORC1 running on sugars.
作者： Gerta Hoxhaj , Jason W. Locasale , Issam Ben-Sahra
DOI: 10.1038/S42255-020-0246-1
关键词:
摘要: The mechanistic target of rapamycin complex 1 (mTORC1) network integrates nutrient and energy signals that regulate metabolism cell growth. Orozco et al. now show the glycolytic intermediate dihydroxyacetone phosphate (DHAP) relays activity to mTORC1 signalling.
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Reuben J Shaw, Nabeel Bardeesy, Brendan D Manning, Lyle Lopez, Monica Kosmatka, Ronald A DePinho, Lewis C Cantley, The LKB1 tumor suppressor negatively regulates mTOR signaling Cancer Cell. ,vol. 6, pp. 91- 99 ,(2004) , 10.1016/J.CCR.2004.06.007
Alejo Efeyan, Lawrence D. Schweitzer, Angelina M. Bilate, Steven Chang, Oktay Kirak, Dudley W. Lamming, David M. Sabatini, RagA, but not RagB, is essential for embryonic development and adult mice Developmental Cell. ,vol. 29, pp. 321- 329 ,(2014) , 10.1016/J.DEVCEL.2014.03.017
Alejo Efeyan, William C. Comb, David M. Sabatini, Nutrient-sensing mechanisms and pathways Nature. ,vol. 517, pp. 302- 310 ,(2015) , 10.1038/NATURE14190
Alexander A Shestov, Xiaojing Liu, Zheng Ser, Ahmad A Cluntun, Yin P Hung, Lei Huang, Dongsung Kim, Anne Le, Gary Yellen, John G Albeck, Jason W Locasale, None, Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step eLife. ,vol. 3, pp. 1- 18 ,(2014) , 10.7554/ELIFE.03342
D. G. Hardie, AMP-activated protein kinase—an energy sensor that regulates all aspects of cell function Genes & Development. ,vol. 25, pp. 1895- 1908 ,(2011) , 10.1101/GAD.17420111
Chen-Song Zhang, Simon A. Hawley, Yue Zong, Mengqi Li, Zhichao Wang, Alexander Gray, Teng Ma, Jiwen Cui, Jin-Wei Feng, Mingjiang Zhu, Yu-Qing Wu, Terytty Yang Li, Zhiyun Ye, Shu-Yong Lin, Huiyong Yin, Hai-Long Piao, D. Grahame Hardie, Sheng-Cai Lin, Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK Nature. ,vol. 548, pp. 112- 116 ,(2017) , 10.1038/NATURE23275
Maria V Liberti, Ziwei Dai, Suzanne E Wardell, Joshua A Baccile, Xiaojing Liu, Xia Gao, Robert Baldi, Mahya Mehrmohamadi, Marc O Johnson, Neel S Madhukar, Alexander A Shestov, Iok I Christine Chio, Olivier Elemento, Jeffrey C Rathmell, Frank C Schroeder, Donald P McDonnell, Jason W Locasale, None, A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product Cell Metabolism. ,vol. 26, pp. 648- 659.e8 ,(2017) , 10.1016/J.CMET.2017.08.017
William J. Quinn, Min Wan, Swapnil V. Shewale, Rebecca Gelfer, Daniel J. Rader, Morris J. Birnbaum, Paul M. Titchenell, mTORC1 stimulates phosphatidylcholine synthesis to promote triglyceride secretion Journal of Clinical Investigation. ,vol. 127, pp. 4207- 4215 ,(2017) , 10.1172/JCI96036
Michael D. Kornberg, Pavan Bhargava, Paul M. Kim, Vasanta Putluri, Adele M. Snowman, Nagireddy Putluri, Peter A. Calabresi, Solomon H. Snyder, Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity Science. ,vol. 360, pp. 449- 453 ,(2018) , 10.1126/SCIENCE.AAN4665
Rosalie E. Lawrence, Roberto Zoncu, The lysosome as a cellular centre for signalling, metabolism and quality control. Nature Cell Biology. ,vol. 21, pp. 133- 142 ,(2019) , 10.1038/S41556-018-0244-7