Polynucleotides. XXII(1). Synthesis and properties of poly 7-deazainosinic acid

摘要: Poly 7-deazainosinic acid has been prepared by the deamination and phosphorylation of tubercidin nucleoside diphosphate was polymerised using polynucleotide phosphorylase. The polymer similar physical properties to poly(I), but a low thermal stability in double-stranded complex with poly(C). Poly(7-deaza I), contrast, forms more stable triple-stranded poly(A) than 2 poly(I). poly(A), presumably due higher pK value.