Structures, properties, and possible biologic functions of polyadenylic acid.

摘要: Our original interest in preparing this review lay the fact that no one had presented a thorough examination of topic, with particular attention to several possible biological functions polyadenylic acid [poly(A)]. However, as we scrutinized literature, point cropped up repeatedly: those engaged research efforts aimed at clarifying physiological significance poly(A) did not make full use current body knowledge concerning chemical properties homopolymer. Similarly, results experiments clarify aspects physical nature were never interpreted terms intracellular functions. Thus, two vast bodies literature exist roughly equal proportions, biochemistry poly(A), other dealing more physically oriented considerations, and amount either group draws on or experience gained by is small. It was therefore obvious us deficit present field research: source all facets biology chemistry existed. Consequences lack discussion between chemists molecular biologists work involving manifest. Experimental based quantitation · polyuridylic (poly(U)] hybrids prepared under conditions wherein triplex [poly(A) 2 poly(U)] may example. Another attitude which structure approached most biologists. Few papers give consideration different structural forms polymer assume. Despite overwhelming evidence from studies unique many respects an alteration experimental induce radical change polymeric structure, little given information. As final example, researchers attempting define poly(A)-binding proteins appear be unaware classes enzymes interact are cognizant consequences partially stacked relevant amino protein binding. regarding are, our opinion, need organization presentation place. We feel such effort will importance both biochemist chemist, since has been published than decade, last ten years have seen significant advances its interactions cations, low-molecular-weight organic compounds, macromolecules. Accordingly, divided manuscript approximately two; first part deals biochemical subcellular because second half concentrates topic—but includes, well, sections metals, complementary monomers, polymers poly(A).