Translocation, t(17;22)(q22;q13), in dermatofibrosarcoma protuberans: a new tumor-associated chromosome rearrangement.

摘要: A translocation, t(17;22)(q22;q13), was identified in two cases of dermatofibrosarcoma protuberans (DP). They bring to four the number DP characterized by an identical which can be considered as a new tumor-associated chromosome rearrangement. To date, this translocation has been found only and its juvenile form, giant-cell fibroblastoma. This finding major consequences. First, it casts light on development significance ring chromosomes consistently harbor sequences derived from 17 22. Second, identification marker, eventually underlying molecular rearrangement, should help classify DP, soft-tissue tumor still uncertain cell origin. In addition, could used differentiate truly benign or malignant entities, order that intermediate malignancy adequately managed.