Acute and Chronic Autoimmune Encephalomyelitis Age, Strain, and Sex Dependency The Importance of the Source of Antigen

摘要: SummaryA variety of conditions favoring the production chronic forms AE existed between optimal for acute (guinea pig antigen in adult Strain 13/N) and strong resistance to (rabbit newborn 2/N). The 2/N guinea pigs autoimmune encephalomyelitis is not absolute. Older female regularly develop severe or lethal when sensitized with spinal cord Freund's complete adjuvant. Guinea a more potent encephalitogen than rabbit Strains 13/N pigs. Sensitized an age group showing no overt clinical signs nevertheless showed striking histological lesions central nervous system.