Dehydroepiandrosterone sulphate: action and mechanism in the brain.
作者： Y. Dong , P. Zheng
DOI: 10.1111/J.1365-2826.2011.02256.X
关键词:
摘要: Dehydroepiandrosterone sulphate (DHEAS) is synthesised from dehydroepiandrosterone by the enzyme sulphotransferase. DHEAS one of most important neurosteroids in brain. The concentration brain sometimes higher than peripheral system. At cellular level, has been shown to modulate a variety synaptic transmission, including cholinergic, GABAergic dopaminergic and glutamatergic transmission. In addition effect on release number neurotransmitters, could also activity postsynaptic receptors. found have multiple effects functions, such as memory enhancing, antidepressant anxiolytic effects, may relationships with many diseases.
sci-hub.se 参考文章(94)
Anne N. Nafziger, David M. Herrington, Trudy L. Bush, Dehydroepiandrosterone and Dehydroepiandrosterone Sulfate: Their Relation to Cardiovascular Disease Epidemiologic Reviews. ,vol. 13, pp. 267- 293 ,(1991) , 10.1093/OXFORDJOURNALS.EPIREV.A036071
R Bergeron, C de Montigny, G Debonnel, Potentiation of neuronal NMDA response induced by dehydroepiandrosterone and its suppression by progesterone: effects mediated via sigma receptors. The Journal of Neuroscience. ,vol. 16, pp. 1193- 1202 ,(1996) , 10.1523/JNEUROSCI.16-03-01193.1996
Etienne-Emile Baulieu, Paul Robel, Non-Genomic Mechanisms of Action of Steroid Hormones Ciba Foundation Symposium 191 - Non-Reproductive Actions of Sex Steroids. ,vol. 191, pp. 24- 51 ,(2007) , 10.1002/9780470514757.CH3
R R Matsumoto, W D Bowen, F O Walker, J M Walker, B De Costa, K C Rice, Sigma receptors: biology and function. Pharmacological Reviews. ,vol. 42, pp. 355- 402 ,(1990)
Maharaj K. Ticku, April Sousa, Interactions of the neurosteroid dehydroepiandrosterone sulfate with the GABA(A) receptor complex reveals that it may act via the picrotoxin site. Journal of Pharmacology and Experimental Therapeutics. ,vol. 282, pp. 827- 833 ,(1997)
Monique Vallée, Willy Mayo, Michel Le Moal, Role of pregnenolone, dehydroepiandrosterone and their sulfate esters on learning and memory in cognitive aging. Brain Research Reviews. ,vol. 37, pp. 301- 312 ,(2001) , 10.1016/S0165-0173(01)00135-7
Vernon Twede, Anthony L. Tartaglia, Douglas F. Covey, Bruce A. Bamber, The neurosteroids dehydroepiandrosterone sulfate and pregnenolone sulfate inhibit the UNC-49 GABA receptor through a common set of residues. Molecular Pharmacology. ,vol. 72, pp. 1322- 1329 ,(2007) , 10.1124/MOL.107.034058
R. Reeves, M. Thiruchelvam, D.A. Cory-Slechta, Expression of behavioral sensitization to the cocaine-like fungicide triadimefon is blocked by pretreatment with AMPA, NMDA and DA D1 receptor antagonists Brain Research. ,vol. 1008, pp. 155- 167 ,(2004) , 10.1016/J.BRAINRES.2004.01.079
Xiuhai Ren, Yukihiro Noda, Takayoshi Mamiya, Taku Nagai, Toshitaka Nabeshima, A neuroactive steroid, dehydroepiandrosterone sulfate, prevents the development of morphine dependence and tolerance via c-fos expression linked to the extracellular signal-regulated protein kinase. Behavioural Brain Research. ,vol. 152, pp. 243- 250 ,(2004) , 10.1016/J.BBR.2003.10.013
Tomoko Nishimura, Tamaki Ishima, Masaomi Iyo, Kenji Hashimoto, Potentiation of Nerve Growth Factor-Induced Neurite Outgrowth by Fluvoxamine: Role of Sigma-1 Receptors, IP3 Receptors and Cellular Signaling Pathways PLoS ONE. ,vol. 3, pp. e2558- ,(2008) , 10.1371/JOURNAL.PONE.0002558