Humoral immunity to commensal oral bacteria in human infants: salivary secretory immunoglobulin A antibodies reactive with Streptococcus mitis biovar 1, Streptococcus oralis, Streptococcus mutans, and Enterococcus faecalis during the first two years of life.

摘要: Secretory immunoglobulin A (SIgA) antibodies reactive with the pioneer oral streptococci Streptococcus mitis biovar 1 and oralis, late colonizer mutans, enteric bacterium Enterococcus faecalis in saliva samples from 10 human infants birth to age 2 years were analyzed. Low levels of salivary SIgA1 SIgA2 whole cells all four species detected within first month after birth, even though S. mutans E. not recovered mouths during study period. Although there was a fivefold increase concentration SIgA between years, no differences concentrations over this time When normalized saliva, these bacteria showed significant decrease age. Adsorption each infant's one produced dramatic reduction recognizing other three species. Sequential adsorption removed antibody bacteria, indicating that directed antigens shared by The induction host limited immune response common are likely involved adherence may be among mechanisms commensal employ persist cavity.