1-Methyl-1,2,3,4-Tetrahydroisoquinoline: A Potent Neuroprotecting Agent

摘要: 1-Methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ), unlike several other tetrahydroisoquinolines, displays neuroprotective properties. To elucidate this action we compared the effects of 1MeTIQ with 1,2,3,4-tetrahydroisoquinoline (TIQ), a compound sharing many activities (e.g., reducing free radicals formed during dopamine catabolism) but offering no clear neuroprotection. We found that compounds similarly inhibit radical generation in an abiotic system, as well indices neurotoxicity, caspase-3 activity, and lactate dehydrogenase release induced by glutamate mouse embryonic primary cell cultures. also prevents glutamate-induced death 45Ca2+ influx, whereas TIQ did not. In vivo microdialysis study has shown kainate-induced excitatory amino acids from rat frontal cortex. Additionally, protects against rotenone-induced mortality, oxidative stress dopaminergic neurodegeneration extrapyramidal structures produced intracerebral injection rotenone. The results suggest offers unique complex mechanism neuroprotection which scavenging properties inhibition excitotoxicity may play very important role, indicates potential therapeutic agent various neurodegenerative illnesses central nervous system.